10 Hydroxycamptothecin - an overview | ScienceDirect Topics
网页3.3 10-hydroxycamptothecin-UFAs. Camptothecin (CPT) is a potent antitumoral agent first separated in 1966 from a Chinese tree, named Camptotheca acuminate (Nyssaceae) [155]. Due to its potential and promising anti-tumor effect, CPT and its synthetic analogs, such as 9-nitro-CPT, 10-hydroxy-CPT (HCPT), irinotecan and topotecan, have received ...
Advances in Antitumor Nano-Drug Delivery Systems of 10-Hydroxycamptothecin
网页2022年9月14日 · 10-Hydroxycamptothecin (HCPT) is a natural plant alkaloid from Camptotheca that shows potent antitumor activity by targeting intracellular topoisomerase I. However, factors such as instability of the lactone ring and insolubility in water have limited the clinical application of this drug.
10-Hydroxycamptothecin | C20H16N2O5 | CID 97226 - PubChem
网页10-Hydroxycamptothecin is a pyranoindolizinoquinoline. ChEBI 10-hydroxycamptothecin is under investigation in clinical trial NCT00956787 (Study of AR-67 ( DB-67 ) in Myelodysplastic Syndrome (MDS)).
SN-38: Uses, Interactions, Mechanism of Action - DrugBank Online
网页2007年11月18日 · 7-ethyl-10-hydroxycamptothecin (SN 38) is a liposomal formulation of the active metabolite of Irinotecan Irinotecan, a chemotherapeutic pro-drug approved for the treatment of advanced colorectal cancer. SN 38 has been used in trials studying the treatment of Cancer, Advanced Solid Tumors, Small Cell Lung Cancer, Metastatic …
10-hydroxycamptothecin: Uses, Interactions, Mechanism of …
网页Explore the full scope of our drug knowledge tailored for pharmaceutical research needs in our data library. Learn more. 10-hydroxycamptothecin is under investigation in clinical trial NCT00956787 (Study of AR-67 (DB-67) in Myelodysplastic Syndrome (MDS)).
Antitumor Mechanism of Hydroxycamptothecin via the …
网页2021年8月13日 · Hydroxycamptothecin (SN38) is a natural plant extract isolated from Camptotheca acuminate. It has a broad spectrum of anticancer activity through inhibition of DNA topoisomerase I, which could affect DNA synthesis and lead to DNA damage.
10-HYDROXYCAMPTOTHECIN - National Center for Advancing …
网页10-Hydroxycamptothecin (10-HCPT), an indole alkaloid isolated from a Chinese tree, Camptotheca acuminate, inhibits the activity of topoisomerase I and has a broad spectrum of anticancer activity in vitro and in vivo.
10-Hydroxycamptothecin - an overview | ScienceDirect Topics
网页10-Hydroxycamptothecin is a chemotherapeutic agent used in cancer therapy that inhibits topoisomerase I and has been found to be highly cytotoxic against colorectal cancer cells. AI generated definition based on: Nanobiomaterials in Medical Imaging, 2016
10 Hydroxycamptothecin - an overview | ScienceDirect Topics
网页The natural 10-hydroxycamptothecin is more active than camptothecin, and is used in China against cancers of the neck and head.
A stabilizer-free and organic solvent-free method to prepare 10 ...
网页2016年6月23日 · 10-Hydroxycamptothecin (10-HCPT) is a type of anticancer alkaloid isolated from the seeds of a native tree in People’s Republic of China, and it is the most potent compound among the 20 isolated monomers. 1 10-HCPT can selectively inhibit topoisomerase 1 and subsequently interfere with DNA replication, 2 which initiates cell …
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