Chondrocyte - Wikipedia
网页The chondrocyte in cartilage matrix has rounded or polygonal structure. The exception occurs at tissue boundaries, for example the articular surfaces of joints, in which chondrocytes may be flattened or discoid. Intra-cellular features are characteristic of a synthetically active cell.
Chondrocytes: anatomy and function - Kenhub
网页2024年3月19日 · The extracellular matrix that is produced by the chondrocytes is important in the maintenance of cartilaginous tissue. Chondrocytes produce the collagen that is found in the matrix as well as the glycosaminoglycans. and proteoglycans. There are three different types of cartilage: hyaline cartilage, elastic cartilage and fibrocartilage.
Histology, Chondrocytes - StatPearls - NCBI Bookshelf
网页2023年4月17日 · Chondrocyte regeneration has contributed to the development of reconstructive procedures. Direct defects on articular cartilage (AC) cause severe pain; such acute and chronic pain could only be minimized with …
Chondrocyte - an overview | ScienceDirect Topics
网页The chondrocyte is the unique resident cell of articular cartilage and thus solely responsible for ECM composition and regulation. Chondrocyte metabolism is influenced by its micro-environment, and in return influences ECM composition, organization and ultimately the mechanical resilience of cartilage 1–3 .
A high-resolution route map reveals distinct stages of chondrocyte ...
网页2022年4月27日 · Articular cartilage damage is a universal health problem. Despite recent progress, chondrocyte dedifferentiation has severely compromised the clinical outcomes of cell-based cartilage regeneration.
The art of building bone: emerging role of chondrocyte-to …
网页2018年6月14日 · To understand the different mechanisms of chondrocyte-to-osteoblast transdifferentiation, it is first important to reference the traditional canonical mechanism of endochondral ossification. 23,24 ...
The Origin and Fate of Chondrocytes: Cell Plasticity in …
网页2023年10月14日 · Purpose of Review Here, we discuss the origin of chondrocytes, their destiny, and their plasticity in relationship to bone growth, articulation, and formation of the trabeculae. We also consider these processes from a biological, clinical, and evolutionary perspective. Recent Findings Chondrocytes, which provide the template for the formation …
Growth Plate Chondrocytes: Skeletal Development, Growth and …
网页2019年11月29日 · 2.2. Investigation of Putative Role of Sox9 in Early Mesenchymal Condensation Formation and Growth Plate Chondrocyte Differentiation. SRY-Box 9 (Sox9) is a transcription factor expressed by cells in mesenchymal condensations and proliferating chondrocytes [].Sox9 is expressed by osteo-chondroprogenitors, as Sox9-cre allele …
Role of Chondrocytes in Cartilage Formation, Progression of ...
网页Articular cartilage (AC) covers the diarthrodial joints and is responsible for the mechanical distribution of loads across the joints. The majority of its structure and function is controlled by chondrocytes that regulate Extracellular Matrix (ECM) turnover and …
Mechanisms of Disease: role of chondrocytes in the pathogenesis …
网页As the disease progresses, osteoarthritic chondrocytes can no longer maintain tissue integrity. Evidence suggests that cell aging is important in the pathogenesis of osteoarthritis.