β-Carboline - Wikipedia
β-Carboline (9 H - pyrido [3,4- b] indole) represents the basic chemical structure for more than one hundred alkaloids and synthetic compounds. The effects of these substances depend on their respective substituent. Natural β-carbolines primarily influence brain functions but can also exhibit antioxidant [1] effects.
Beta Carboline - an overview | ScienceDirect Topics
Beta Carboline. In subject area: Medicine and Dentistry. The β-carbolines constitute a group of natural and synthetic alkaloids comprising a tricyclic pyrido [3,4-b]indole ring structure at different levels of unsaturation (dihydro-, tetrahydro, and aromatic …
Beta-Carboline - an overview | ScienceDirect Topics
Beta-carbolines are precursor neurotoxins synthesized from tryptophan that can lead to the formation of beta-carbolinium ions in the brain, potentially causing neuronal death and symptoms of Parkinson's disease. AI generated definition based on: Neurotoxicology and Teratology, 2002. About this page.
Beta-Carboline - an overview | ScienceDirect Topics
β-Carbolines comprise a class of compounds that have elicited interest from a number of different disciplines. Initially, β-carbolines have been identified as alkaloids in plants that have a long tradition in ethnopharmacology and are active constituents in hallucinogenic plants employed in South American Indian cultures [1].
A review on medicinal importance, pharmacological activity ...
Beta-carboline alkaloids exhibited a wide range of psychopharmacological effects by binding to benzodiazepine, imidazoline, serotonin and opiate receptors as well as MAO inhibition. Ingestion of ayahuasca (herbal preparation) containing harmine improved psychometric measures of panic and hopelessness in humans [12] .
A comprehensive overview of β-carbolines and its derivatives ...
2021年11月15日 · β-Carboline alkaloids are a family of natural and synthetic products with structural diversity and outstanding antitumor activities. This review summarizes research developments of β-carboline and its derivatives as anticancer agents, which focused on both natural and synthetic monomers as well as d ….
Synthesis of β-carbolines (microreview) | Chemistry of ...
2017年1月18日 · β-Carbolines are an important class of heterocyclic compounds because of their broad spectrum of biological profiles. Consequently, many methodologies have been described to construct the β-carboline scaffold. This microreview summarizes these newly developed synthetic approaches. Introduction.
Bioactive β-Carbolines in Food: A Review - PubMed
2019年4月11日 · Harman and norharman, two neuroactive β-carbolines, are present in several plants and in thermally processed foods. They exhibited a wide spectrum of biological and pharmacological effects, including antioxidant, neuroprotective, and anti-inflammatory effects.
β-Carbolines: Occurrence, Biosynthesis, and Biodegradation
2011年11月10日 · Studies clearly demonstrated biosynthesis of β-carbolines (βCs) in animals and humans. Precursor compounds include serotonin (syn. 5-hydroxytryptamine), tryptamine, and tryptophan with either acetaldehyde or pyruvate as cosubstrates. βCs are...
beta-Carboline alkaloids: biochemical and pharmacological ...
beta-Carboline alkaloids are a large group of natural and synthetic indole alkaloids with different degrees of aromaticity, some of which are widely distributed in nature, including various plants, foodstuffs, marine creatures, insects, mammalians as well as human tissues and body fluids.