Orexin - Wikipedia
Orexin (/ ɒ ˈ r ɛ k s ɪ n /), also known as hypocretin, is a neuropeptide that regulates arousal, wakefulness, and appetite. [5] It exists in the forms of orexin-A and orexin-B.
Orexins: Understanding Its Role in Sleep | Sleep Foundation
2023年12月22日 · Among the many functions of orexins discovered, they appear to play an important role in sleep, energy metabolism, and mood. Recent research has offered a hypothesis that attempts to explain all of the seemingly diverse roles of orexins in the body .
Orexin neurons inhibit sleep to promote arousal - Nature
2022年7月18日 · Orexin (Ox; also called hypocretin) neurons in the lateral hypothalamus play an indispensable role in stabilizing and maintaining wakefulness. For example, loss of Ox- producing neurons in...
The role of orexin in motivated behaviours - Nature
2014年10月10日 · Orexins are lateral hypothalamic neuropeptides that have a highly important role in the regulation of wakefulness. To support feeding behaviour, orexin neurons are excited by food-related cues...
The physiological role of orexin/hypocretin neurons in ...
This review discusses the mechanism by which orexins maintain sleep/wakefulness states and how this mechanism relates to other systems that regulate emotion, reward, and energy homeostasis. Keywords: orexin, hypocretin, sleep, hypothalamus, optogenetics, neuropeptide.
Orexin System: The Key for a Healthy Life - PMC
Orexin A and B are excitatory hypothalamic neuropeptides playing a relevant role in different physiologic functions such as sleep/wake rhythms and thermoregulation, control of energy metabolism, cardiovascular responses, feeding behavior, and …
Orexin - an overview | ScienceDirect Topics
Orexin. Orexin is a neuropeptide produced in the hypothalamus that regulates the sleep-wake cycle and autonomic functions in the brain. It includes two types of orexin (orexin A and orexin B) and two types of orexin receptors (OX1R and OX2R) that …
The neural circuit of orexin (hypocretin): maintaining sleep ...
2007年2月14日 · The orexin (hypocretin) system regulates sleep and wakefulness through interactions with systems that regulate emotion, reward and energy homeostasis.
Orexin System: The Key for a Healthy Life - Frontiers
2017年5月30日 · Orexin neurons are “multi-tasking” neurons regulating a set of vital body functions, including sleep/wake states, feeding behavior, energy homeostasis, reward systems, cognition and mood. Furthermore, a dysfunction of orexinergic system may underlie different pathological conditions.
The Orexin/Receptor System: Molecular Mechanism and …
2018年6月28日 · Orexins, also known as hypocretins, are two neuropeptides secreted from orexin-containing neurons, mainly in the lateral hypothalamus (LH). Orexins orchestrate their effects by binding and activating two G-protein-coupled receptors (GPCRs), orexin receptor type 1 (OX1R) and type 2 (OX2R).