The MYC oncogene — the grand orchestrator of cancer growth …
2021年9月10日 · MYC leads to cancer initiation and maintenance by regulating the host immune system through mechanisms involving immune checkpoints, specific receptors and secreted cytokines. Currently, no...
MYC: a multipurpose oncogene with prognostic and therapeutic ...
2021年8月9日 · MYC oncogene is a transcription factor with a wide array of functions affecting cellular activities such as cell cycle, apoptosis, DNA damage response, and hematopoiesis. Due to the multi-functionality of MYC, its expression is regulated at multiple levels.
The spliceosome is a therapeutic vulnerability in MYC-driven cancer
2015年9月17日 · MYC (also known as c-MYC) overexpression or hyperactivation is one of the most common drivers of human cancer. Despite intensive study, the MYC oncogene remains recalcitrant to therapeutic inhibition. MYC is a transcription factor, and many of its pro-tumorigenic functions have been attributed to its ability to regulate gene expression programs.
The effects of MYC on tumor immunity and immunotherapy
2023年3月25日 · The abnormal expression of MYC is one of the most common carcinogenic events in human cancer. MYC modulates immune effector cells and immune regulatory factors in the tumor immune...
Regulation of cancer cell metabolism: oncogenic MYC in the …
2020年7月10日 · The MYC family of oncoproteins, including MYC, MYCL, and MYCN, is an essential, master regulator of metabolic reprogramming in a broad spectrum of human cancers. 8, 9 While MYC expression is...
Tilting MYC toward cancer cell death - PMC
MYC oncoprotein promotes cell proliferation and serves as the key driver in many human cancers; therefore, considerable effort has been expended to develop reliable pharmacological methods to suppress its expression or function. Despite impressive advances, MYC-targeting drugs have not reached the clinic. Recent advances suggest that within a ...
MYC Gene - GeneCards | MYC Protein | MYC Antibody
2024年10月2日 · MYC (MYC Proto-Oncogene, BHLH Transcription Factor) is a Protein Coding gene. Diseases associated with MYC include Burkitt Lymphoma and High-Grade B-Cell Lymphoma Double-Hit/Triple-Hit. Among its related pathways are Prolactin Signaling and Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.
MYC amplifies gene expression through global changes in …
2022年1月25日 · c-MYC (MYC) is an oncogenic transcription factor that is overexpressed in the majority of malignancies (Vita and Henriksson, 2006) and is associated with aggressive tumor progression and poor patient survival (Spencer and Groudine, 1991).
A SUMOylation-dependent transcriptional subprogram is required for Myc ...
Myc is an oncogenic transcription factor frequently dysregulated in human cancer. To identify pathways supporting the Myc oncogenic program, we used a genome-wide RNA interference screen to search for Myc - synthetic lethal genes and uncovered a role for the SUMO-activating enzyme (SAE1/2).
Estrogen-independent Myc overexpression confers endocrine …
2019年2月1日 · Abstract. Approximately 30% of metastatic breast cancers harbor estrogen receptor α (ERα) mutations associated with resistance to endocrine therapy and reduced survival.
- 一些您可能无法访问的结果已被隐去。显示无法访问的结果