Lentivirus - Wikipedia
Lentivirus is a genus of retroviruses that cause chronic and deadly diseases characterized by long incubation periods, in humans and other mammalian species. [2] . The genus includes the human immunodeficiency virus (HIV), which causes AIDS.
Lentiviral vector in gene therapy - Wikipedia
The lentivirus is a retrovirus, meaning it has a single stranded RNA genome with a reverse transcriptase enzyme. Lentiviruses also have a viral envelope with protruding glycoproteins that aid in attachment to the host cell's outer membrane.
Lentiviral Guide - Addgene
Lentiviral tropism is determined by the ability of the viral envelope protein to interact with receptors at the host cell surface. The VSV-G envelope protein is commonly used in lentiviral particle production because it confers broad tropism over a range of species and cell types.
The Revival of Lentiviral Vectors - Nature
Scientists are finally unlocking the potential of lentiviral vectors for gene, cell and immunotherapies.
Clinical use of lentiviral vectors - PubMed
2020年7月18日 · Lentiviral vectors, derived from the human immunodeficiency virus, have been extensively investigated and optimized over the past two decades.
Clinical use of lentiviral vectors | Leukemia - Nature
2018年3月22日 · In this review, we discuss several aspects of lentiviral vectors that will be of interest to clinicians, including an overview of lentiviral vector development, the current uses of viral...
Lentiviral Vectors for T Cell Engineering: Clinical Applications ...
Lentiviral vectors have played a critical role in the emergence of gene-modified cell therapies, specifically T cell therapies.
Lentiviral Gene Therapy for Cerebral Adrenoleukodystrophy
2024年10月9日 · At a median follow-up of 6 years after lentiviral gene therapy, most patients with early cerebral adrenoleukodystrophy and MRI abnormalities had no major functional disabilities.
Lentiviral Vector Bioprocessing - PMC
Lentiviral vectors (LV) are commonly used in cell and gene therapies for the transfer and integration of transgenes of interest into recipient cells for therapeutic benefit . As vectors, they are capable of transducing dividing and non-dividing cells such as neurons, haematopoietic stem cells and those of the immune system, notably T-cells ...
The very stable lentiviral vector - Cell Press
2024年3月14日 · Lentiviruses are a type of retrovirus that cause slowly progressing diseases. Useful for their ability to stably transfer genetic material to target cells independently of cell-cycle status, LVs are subject to cell-intrinsic species-specific restrictions.