CYP11B2 Gene - GeneCards | C11B2 Protein | C11B2 Antibody
2024年10月1日 · This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the mitochondrial inner membrane.
CYP11B2 gene - MedlinePlus
The CYP11B2 gene provides instructions for making an enzyme called aldosterone synthase (previously known as corticosterone methyloxidase). This enzyme is found in the adrenal glands, which are located on top of the kidneys. Aldosterone synthase is a member of the cytochrome P450 family of enzymes. These enzymes are involved in the formation ...
Molecular and Epigenetic Control of Aldosterone Synthase, CYP11B2 …
The zona glomerulosa, the outer zone of the gland, expresses aldosterone synthase, CYP11B2, which catalyzes the synthesis of aldosterone [13]. The renin-angiotensin system (RAS) and potassium regulate CYP11B2 expression. The zona fasciculata produces cortisol.
CYP11B2 cytochrome P450 family 11 subfamily B member 2
CYP11B2 polymorphism is an independent predictor for atrial fibrillation development in hypertrophic cardiomyopathy patients. CYP11B2 genotype were associated to type 2 diabetes mellitus. Heterogenous immunolocalization of CYP11B2 and diffuse immunoreactivity of CYP11B1 were detected.
Structural and functional insights into aldosterone synthase ...
2021年4月19日 · CYP11B2 performs a three-reaction series, starting with 11-deoxycorticosterone 11β-hydroxylation to yield corticosterone. Corticosterone is then hydroxylated at position 18 to form 18-hydroxycorticosterone, and finally position 18 is further oxidized to yield aldosterone (3).
CYP11B2 cytochrome P450 family 11 subfamily B member 2
2016年11月21日 · Clinical resource with information about CYP11B2, Corticosterone 18-monooxygenase deficiency, Corticosterone methyloxidase type 2 deficiency, and available tests.
Discovery and in Vivo Evaluation of Potent Dual CYP11B2 …
Aldosterone synthase (CYP11B2) is responsible for the final three steps of aldosterone synthesis and thus is a viable therapeutic target. A series of imidazole derived inhibitors, including clinical candidate 7n , have been identified through design and structure–activity relationship studies both in vitro and in vivo.
The CYP11B subfamily - PubMed
The production of glucocorticoids and mineralocorticoids takes place in the adrenal gland and the final steps are catalyzed by 2 mitochondrial cytochromes P450, CYP11B1 (11β-hydroxylase or P45011β) and CYP11B2 (aldosterone synthase or P450aldo).
Immunohistochemistry of the Human Adrenal CYP11B2 in Normal ... - PubMed
The CYP11B2 enzyme is the terminal enzyme in the biosynthesis of aldosterone. Immunohistochemistry using antibodies against CYP11B2 defines cells of the adrenal ZG that synthesize aldosterone.
CYP11B2 cytochrome P450 family 11 subfamily B member 2 …
2024年3月1日 · This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the mitochondrial inner membrane.
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