For the first time, a molecular mechanism is identified, for experimental acceleration and deceleration (rejuvenation) of sperm epigenetic aging.

Structural studies reveal the mechanism by which the mRNA nuclear export machinery engages with nascent transcripts through interaction with the cap binding complex.

Center for Brain Injury and Repair, Department of Neurosurgery, University of Pennsylvania, Philadelphia, USA Center for Neurotrauma, Neurodegeneration, and Restoration, Corporal Michael J. Crescenz ...

In the DDM, noisy evidence is accumulated into a decision variable until reaching one of the two bounds, representing commitment to one of two choices (e.g., left or right). In general, the average ...

Wong et al. (2019) used a sensory preconditioning protocol to examine how sensory and fear memories are integrated in the rat medial temporal lobe. In this protocol, rats integrate a sound-light ...

Pathogenic activating point mutations in the LRRK2 kinase cause autosomal-dominant familial Parkinsońs disease (PD). In cultured cells, mutant LRRK2 causes a deficit in de novo cilia formation and ...

In this study, we investigated the neuronal activity of the dentate gyrus (DG) with electrophysiological and optical imaging tools during sleep-wake cycles. We found that the activity of major ...

National Research Center for Protozoan Diseases, Obihiro University of Agriculture Veterinary Medicine, Inada-cho, Obihiro, Japan Department of Veterinary Medicine, Agriculture College of Yanbian ...

The accumulation of SIRT4 in the nuclei of kidney cells drives kidney fibrosis, so blocking the movement of this protein could be a potential therapeutic strategy against fibrosis.

m6A is the most widespread mRNA modification and is primarily implicated in controlling mRNA stability. Fundamental questions pertaining to m6A are the extent to which it is dynamically modulated ...

State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, China Department of Endodontics, West China ...

Chondrocyte columns, which are a hallmark of growth plate architecture, play a central role in bone elongation. Columns are formed by clonal expansion following rotation of the division plane, ...