This manuscript reports on the crystal structures of two glycosaminoglycan (GAG) lyases from the PL35 family, along with in vitro enzyme activity assays and comprehensive structure-guided mutagenesis.

National Glycoengineering Research Center and Shandong Key Laboratory of Carbohydrate Chemistry and Glycobiology, Shandong University, Qingdao, China MOE Key Laboratory of Evolution and Marine ...

To her disbelief, Sanfillipo Syndrome, had symptoms that her daughter had been experiencing, which she thought were just ...

The red module may be beneficial in aging via the preferential degranulation of mast cells; release of glucosamines, heparin (a glycosaminoglycan) and histamine, which induce vasodilatation ...

With oncofetal CS being a broadly expressed target across solid tumor models, we decided to explore this glycosaminoglycan as a target for CAR Tcell therapy. We first tested the levels of oncofetal CS ...

Teams of undergraduate students, faculty members and New Haven residents competed in New Haven Reads’ 12th annual Spelling ...

Recent research has uncovered a pivotal role for hyaluronic acid (aka hyaluronan, HA), a glycosaminoglycan found in the extracellular matrix of tissues like cartilage, in this immune modulation.

▎药明康德内容团队编辑（来源：中国科学院昆明植物研究所）糖尿病足溃疡是糖尿病常见的高危并发症之一。目前，糖尿病足溃疡的临床治疗方法包括抗生素、生长因子、敷料和皮肤替代物等，但治疗效果有限。因此，糖尿病足溃疡在临床上亟需安全有效的新型治疗药物。中国科学院昆明植物研究所研究员吴明一团队聚焦于天然多糖的结 ...

Natural scaffolds are made up of protein or carbohydrates with particular biochemical, mechanical, and structural properties. They can be derived from plant or animal sources, and are mostly found ...

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Advances in molecular and cell biology have led to an expansion in our knowledge and understanding of the processes involved in wound healing. We review existing and potential therapies modulating ...

They bind to a type of glycosaminoglycan commonly expressed by cancer cells but not by healthy cells. This makes them well suited for delivering toxic payloads to tumors while leaving normal ...