RNA-sequencing has become a cornerstone in the study of gene expression, offering insights beyond mere mRNA transcript ...

RNA-sequencing has become a cornerstone in the study of gene expression, offering insights beyond mere mRNA transcript ...

This means interactions can be analysed between large macromolecular assemblies such as the ribosome or spliceosome and individual ligands. Contact the Biosciences research team for more information.

Using NGS in prognostic assessments enhances myelofibrosis prognosis and survival estimates, representing a step toward personalized medicine in myelofibrosis.

We study minor spliceosome which is a parallel pre-mRNA splicing machinery in the cells of most metazoan organisms. Our main aim is to investigate mechanism and regulation of this nuclear machinery, ...

We study regulation of gene expression by the minor spliceosome. This parallel pre-mRNA splicing machinery functions during the nuclear RNA processing phase and regulates cellular mRNA levels. We ...

The accumulation of SIRT4 in the nuclei of kidney cells drives kidney fibrosis, so blocking the movement of this protein could be a potential therapeutic strategy against fibrosis.

2 [Alt text] From left to right, the figure outlines key elements of posttranscriptional pre-mRNA splicing: an RNA transcript (pre-mRNA) displaying introns and exons, and six common splicing ...

However, whether BCAS2 has other functions within the nucleus remains largely unknown. Here, we show that BCAS2 is essential for primitive hematopoiesis in zebrafish and mouse embryos. The activation ...

The vast majority of introns are removed by the major spliceosome, a 60 S complex containing five small nuclear RNAs (snRNAs: U1, U2, U4, U5 and U6) and well over 50 different polypeptides (Fig.