a FDA = Food and Drug Administration; CYP2C9 = cytochrome P-450 isoenzyme 2C9; VKORC1 = vitamin K epoxide reductase complex subunit 1; UGT1A1 = uridine diphosphate-glucuronosyltransferase 1A1 ...

Objective To assess the effect of sildenafil, a phosphodiesterase type 5 inhibitor, on digital ulcer (DU) healing in systemic sclerosis (SSc). Methods Randomised, placebo-controlled study in patients ...