在最近发表在《分子细胞》杂志上的一篇文章中，研究人员提供了一个有价值的数据资源，可以深入了解控制人类免疫缺陷病毒 (HIV) 在人脑中整合和表达的细胞和遗传机制。背 景HIV 在感染后的前两周内进入中枢神经系统 ...

*仅供医学专业人士阅读参考对于阿尔茨海默病（AD）患者来说，在痴呆症状出现之前，β淀粉样蛋白（Aβ）斑块沉积和tau蛋白缠结等病理变化会逐步引发轻度认知障碍（MCI）。MCI是AD发展的早期阶段，可以观察到患者皮质Aβ水平升高和小胶质细胞的活化。然而 ...

Understanding the role of microglia is helping scientists work toward improved treatments for neurodegenerative diseases.

Reducing microglial activity in the presence of apolipoprotein E4 (APOE4) has uncovered a mechanism associated with the deposition of misfolded amyloid and tau in a novel mouse model of Alzheimer’s ...

We are interested in how novel non-neuronal mechanisms contribute to drug addiction. There is growing recognition that microglial proinflammatory actions play an important role in the brain’s response ...

To investigate the effect of LS, the team chose microglial cell lines (BV-2 or 6-3). They found that a decrease of sodium ...

The microglia, in turn, seem to benefit, revving up metabolism and phagocytosis. The liver protein ApoA-I was particularly good at bolstering the latter. Overall, the findings suggest that the brain’s ...

Researchers have developed a promising nasal spray therapy targeting neuroinflammation in Alzheimer’s disease, potentially ...

POLK expression in neurons and report an important observation that POLK exhibits an age-dependent change in subcellular localization, from the nucleus in young tissue to the cytoplasm in old tissue.

And the reasons for that are not well understood,” said Cree. Accumulating disability absent relapse activity could stem from ...