Heterocycles, molecular rings found in many pharmaceuticals, have a reputation for stubbornly resisting modification. That is, in a heterocycle, heteroatoms of one type aren’t easily swapped for ...

Kevin Shea focuses on organic chemistry. His lab uses organic synthesis to investigate new methods for carbon­-carbon bond formation and to develop syntheses of biologically active molecules.

Heterocycles found in numerous drugs could be modified more easily and directly through this method. This discovery, which allows one atom to be changed at a time without having to rebuild the whole ...

G. Tobajas-Curiel, Q. Sun, J. K. M. Sanders, P. Ballester, C. A. Hunter. Solvation Rules: Aromatic Interactions Outcompete Cation-π Interactions in Synthetic Host ...

In addition, by modifying different electron-donating groups on the nitrogen heterocycles of the nitrogen-phosphine chelating ligands, the team developed a series of solution-processed color-tunable ...

Saluste, C.G., Ortega M.A., Pastor, J. et al. “Fragment-Hopping-Based Discovery of a Novel Chemical Series of Proto-Oncogene PIM-1 Kinase Inhibitors. Plos One, 2012 ...

Rita Bernadett Vlocskó is a graduate student in green organic chemistry at the University of Massachusetts, Boston, where her primary focus is on novel green and sustainable design and synthesis of ...

Dr. Ricca is a computational chemist with over 25 years of experience in modeling the formation, reactivity, spectroscopy, and optical properties of organic compounds in the gas-phase and in ices. She ...