They bind to a type of glycosaminoglycan commonly expressed by cancer cells but not by healthy cells. This makes them well suited for delivering toxic payloads to tumors while leaving normal ...
This manuscript reports on the crystal structures of two glycosaminoglycan (GAG) lyases from the PL35 family, along with in vitro enzyme activity assays and comprehensive structure-guided mutagenesis.
National Glycoengineering Research Center and Shandong Key Laboratory of Carbohydrate Chemistry and Glycobiology, Shandong University, Qingdao, China MOE Key Laboratory of Evolution and Marine ...