During PINK1- and Parkin-mediated mitophagy, autophagy adaptors are recruited to damaged mitochondria to promote their selective degradation. Autophagy adaptors such as optineurin (OPTN) and NDP52 ...

Osteoarthritis (OA) is the most common type of arthritis characterized by progressive cartilage degradation, with its pathogenesis closely related to chondrocyte autophagy. Chondrocytes are the only ...

Humans and fruit flies both may become forgetful as they age. But because fruit flies have a lifespan of only about two months, they can be a useful model for understanding the cognitive decline that ...

Monocrotaline (MCT), a major pyrrolizidine alkaloid, is well-known for its high liver toxicity. Dysregulation of autophagy induced apoptosis can lead to various liver diseases, including those induced ...

However, irinotecan also induced an impairment of the autophagic flux mediated by alkalisation of lysosomal pH. Re-acidification of lysosomal pH abolished irinotecan-induced autophagy impairment and ...

3. Cellular Repair Through Autophagy During the fasting period, cells initiate a process called autophagy, where damaged cell ...

This clustering increases the curvature of the membrane caused by the receptors. Initially, the IDR tentacles are extended. They make contact with the autophagy machinery and direct it toward the ...

uk-erlangen.de Objectives Autophagy has recently been shown to regulate osteoclast activity and osteoclast differentiation. Here, we aim to investigate the impact of autophagy inhibition as a ...

Researchers at Baylor College of Medicine, the Jan and Dan Duncan Neurological Research Institute (Duncan NRI) at Texas ...