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腾讯网
18 天
Nature子刊:王爱军团队等开发可酸降解的LNP,增强mRNA递送
该研究开发了一种名为“azido-acetal”(叠氮基-缩醛)的可酸降解连接子,利用其合成了由聚乙二醇脂质、阴离子脂质和阳离子脂质组成的可降解脂质,并以此为基础合成了在内体中快速水解的LNP(RD-LNP)。在体外和体内实验中,RD-LNP显著提高了LNP-mRNA复合物的 ...
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