2 [Alt text] From left to right, the figure outlines key elements of posttranscriptional pre-mRNA splicing: an RNA transcript (pre-mRNA) displaying introns and exons, and six common splicing ...

The vast majority of introns are removed by the major spliceosome, a 60 S complex containing five small nuclear RNAs (snRNAs: U1, U2, U4, U5 and U6) and well over 50 different polypeptides (Fig.

We study minor spliceosome which is a parallel pre-mRNA splicing machinery in the cells of most metazoan organisms. Our main aim is to investigate mechanism and regulation of this nuclear machinery, ...

We study regulation of gene expression by the minor spliceosome. This parallel pre-mRNA splicing machinery functions during the nuclear RNA processing phase and regulates cellular mRNA levels. We ...

RNA-sequencing has become a cornerstone in the study of gene expression, offering insights beyond mere mRNA transcript ...

The accumulation of SIRT4 in the nuclei of kidney cells drives kidney fibrosis, so blocking the movement of this protein could be a potential therapeutic strategy against fibrosis.

In contrast, the frequency of silencing sequences derived from E. coli DNA is much lower. Many of these sequences contain polypyrimidine tracts, and we are pursuing the idea that they act as ...

RNA-sequencing has become a cornerstone in the study of gene expression, offering insights beyond mere mRNA transcript ...

The splicing of pre-mRNAs involves the selection of 5' and 3' splice sites for joining by a spliceosome based reaction. The spliceosome contains five small nuclear RNA particles (snRNPs) as well as a ...

However, whether BCAS2 has other functions within the nucleus remains largely unknown. Here, we show that BCAS2 is essential for primitive hematopoiesis in zebrafish and mouse embryos. The activation ...

Using NGS in prognostic assessments enhances myelofibrosis prognosis and survival estimates, representing a step toward personalized medicine in myelofibrosis.