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生物通
18 小时
科学家使用微细胞无人机运送肺癌杀伤药物
为了实现这一目标,研究人员利用来自人类红细胞的细胞外囊泡(EVs)作为天然载体,将抗癌ASOs运送到肿瘤部位。为了将装载ASOs的EV引导到肿瘤部位,EGFRs靶向部分被设计到EV表面。这使得EV能够锁定癌细胞。此外,负载ASOs的电动汽车在各种肺癌模型(包括患者来源的细胞)中显示出强大的抗癌作用。ASOs的特殊设计使它们能够抑制突变的EGFR,而不影响正常的EGFR。他们还证明了负载ASOs的R ...
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