“For the first time, the present study revealed a critical role for protein palmitoylation in the development of a DNA damage ...

Hou, Chen et al. show that aged bone marrow macrophages propagate senescence to multiple tissues in vivo, through extracellular vesicles containing PPARα-targeted microRNAs. They demonstrate the ...

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The analysis identifies four main pathogenetic categories: entities characterized by senescence, sharing clinical features with idiopathic pulmonary fibrosis (IPF), including subsets of fibrosing ...

Background: Intervertebral disc degeneration (IDD) progression involves multiple factors, including loss of nucleus pulposus cells and extracellular matrix as the basic pathological mechanism of ...

F rom fruit flies that survive a mere two weeks to the giant tortoises of the tropics that can live for nearly 200 years, ...

A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science ...

1 Campus for Ageing and Vitality, Newcastle University, Newcastle, United Kingdom 2 Center for Healthy Aging, Institute of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen, ...

As noted in the Abstract of the paper, cells may undergo senescence in response to DNA damage, which is associated with cell cycle arrest, altered gene expression and altered cell morphology.

Mechanical damage to the cell membrane was previously believed to trigger two simple cellular outcomes: recovery or death. In this study, however, the researchers uncovered a third outcome – cellular ...

This leads to activation of cGAS-STING pathway and type-I interferon (IFN-I) signaling, as well as to the induction of cellular senescence and senescence-associated secretory phenotype (SASP) ...