Working with animals, Penn researchers modified the mRNA vaccine to target C. difficile, an infection that kills 30,000 in ...

C. difficile is a bacterium that can cause infection with symptoms ranging from diarrhea to deadly colon damage. It spreads quickly via its hard-to-kill spores and commonly infects vulnerable ...

"C. diff can persist in multiple forms in the gut, including in biofilms and as an incredibly hardy spore, making it uniquely difficult to treat," said Joseph P. Zackular, PhD, co-director of the ...

The product is based on purified Firmicutes bacterial spores delivered in an oral capsule that is designed to encourage the regrowth of healthy bacteria after antibiotic treatment for C.

Clostridioides difficile, a spore-forming and anaerobic gram-positive bacterium, causes a wide-spectrum diarrheal disease that can ultimately lead to life-threatening conditions such as toxic ...

Pfizer's vaccine for Clostridium difficile (C. diff) looks like it may join a growing list of candidates that have been shelved or delayed, after the shot failed to meet its primary objective in a ...