Center for Brain Injury and Repair, Department of Neurosurgery, University of Pennsylvania, Philadelphia, USA Center for Neurotrauma, Neurodegeneration, and Restoration, Corporal Michael J. Crescenz ...

For the first time, a molecular mechanism is identified, for experimental acceleration and deceleration (rejuvenation) of sperm epigenetic aging.

Structural studies reveal the mechanism by which the mRNA nuclear export machinery engages with nascent transcripts through interaction with the cap binding complex.

In the DDM, noisy evidence is accumulated into a decision variable until reaching one of the two bounds, representing commitment to one of two choices (e.g., left or right). In general, the average ...

Wong et al. (2019) used a sensory preconditioning protocol to examine how sensory and fear memories are integrated in the rat medial temporal lobe. In this protocol, rats integrate a sound-light ...

Pathogenic activating point mutations in the LRRK2 kinase cause autosomal-dominant familial Parkinsońs disease (PD). In cultured cells, mutant LRRK2 causes a deficit in de novo cilia formation and ...

In this study, we investigated the neuronal activity of the dentate gyrus (DG) with electrophysiological and optical imaging tools during sleep-wake cycles. We found that the activity of major ...

Nearly a thousand diverse adaptive mutants converge into a handful of groups for which fitness responds the same way to ...

This study presents a valuable finding on the function of the gene Cst7 in sex-divergent pathological changes in microglia in a mouse model of amyloid-driven Alzheimer's disease. The evidence ...

Chromatin accessibility discriminates stem from mature cell populations, enabling the identification of primitive stem-like cells in primary tumors, such as glioblastoma (GBM) where self-renewing ...

Department of Neurology, Weill Institute for Neuroscience, University of California San Francisco, San Francisco, California Department of Psychiatry, Weill Institute for Neuroscience, University of ...

Learning and decision-making are interactive processes, yet cognitive modeling of error-driven learning and decision-making have largely evolved separately. Recently, evidence accumulation models ...