Novel method identified protein degraders that target Pin1, a protein involved in pancreatic cancer development.

In drug discovery, targeted protein degradation is a method that selectively eliminates disease-causing proteins. A ...

The team reports today in the Proceedings of the National Academy of Sciences that it has designed agents that not only bind tightly to Pin1 but are designed to cause its destabilization and cellular ...

The process of identifying promising small molecule drug candidates that target cancer checkpoints may become faster and ...

DNA is negatively charged, due to the phosphate groups in its phosphate-sugar backbone, so histones bind with DNA very tightly. The basic repeating structural (and functional) unit of chromatin is ...

SOMAmer reagents are synthetic ssDNA sequences with hydrophobic appendages that tightly bind a specific protein target, enabling unprecedented multiplexing power across a 10-log dynamic range. Unlike ...

Whether you choose to refrigerate or freeze your pineapple casserole, it's important to watch for a few signs to ensure it's ...

The Somascan Assay uses Slow Off-rate Modified Aptamers (called SOMAer regents) to provide 7,000 highly reproducible measurements (-5% CV) of circulating proteins from a single, 55 ul sample of plasma ...

Antibodies bind to specific antigens on pathogens ... Once bound, the antigens - and the substances they are found on - are merged tightly together. This makes them easier to identify and deal ...

Gabe Vasquez will keep his seat in Congress in New Mexico's hotly contested 2nd Congressional District, according to unofficial results. Both Vasquez and his Republican challenger Yvette Herrell ran ...