Loss of normal p53 function has been associated with resistance to both chemotherapy and radiotherapy. Introduction of wild-type (wt) p53 by means of adenoviral vectors has been shown to inhibit ...

However, optimal implementation of EGFR inhibitors as radiosensitizers depends, in part, on a better understanding of the mechanisms of radiosensitization. Preclinical studies provide important ...

"I have a long research interest in methods of enhancing radiosensitization such as combinations of chemotherapy or targeted therapy with radiotherapy. My current laboratory interests are directed at ...

Other replicative and non-replicative vectors containing genes that produce chemosensitization and radiosensitization are being studied. Additional studies are being conducted with novel ...

Summary and Introduction Clinical Application—Disease Entities Theoretical Framework for Therapy−The 'Steel Paradigm' Conclusion References Theoretical Framework for Therapy−The 'Steel ...