One such compound, the 3,4,5-trisubstituted piperidine Ro 66-1132 (Fig. 4a), was effective in lowering blood pressure and reducing end-organ damage in double transgenic rats engineered to express ...
Biotransformation of methylphenidate by the carboxylesterase CES1A1 is rapid and extensive leading to the main, de-esterified metabolite α-phenyl-2-piperidine acetic acid (ritalinic acid), which ...