Furthermore, the study of nucleobase sequences across different species can provide valuable insights into evolutionary relationships and the history of life on Earth. Comparative genomics, which ...

Thanks to a serendipitous discovery and a lot of painstaking work, scientists can now build biohybrid molecules that combine ...

(Image: Public Domain) Uracil was first discovered in 1900 by the Italian chemist Alberto Ascoli, who isolated it from yeast nucleic acids. However, its role as a nucleobase in RNA was not established ...

First, it doesn’t require any of the nucleobase modifications that conventional mRNA vaccines depend on for improved stability. Second, it simply uses “naked” RNA injected directly without a ...

Scientists have discovered a method to create biohybrid molecules combining DNA and proteins using bacterial enzymes. This ...

Naturally occurring peptide–nucleobase hybrids are rare. Here Pei et al. report the discovery and biosynthetic studies of the first peptide–nucleobase hybrid catalyzed by an RRE–YcaO ...

Identification of potent COVID-19 main protease inhibitors by loading of favipiravir on Mg12O12 and Zn12O12 nanoclusters: an in silico strategy for COVID-19 treatment.

The P-loop phosphotransferase fold of the kinase is embellished by a unique “G-loop” element that accounts for guanine nucleotide specificity. Mutations of amino acids that contact the guanine ...

Metabolic rewiring is essential for osteoclast differentiation and bone resorption. This study shows that glutaminolysis ...

Notably, the deoxy guanosine riboswitch achieves its specificity by modifying key interactions involving the nucleobase and through rearrangement of the ligand-binding pocket, so as to accommodate the ...

Nucleotides are the building blocks of DNA and RNA. Each nucleotide consists of a nucleobase, a phosphate group, and a sugar. Each nucleotide in DNA has one of four nucleobases: adenosine ...