Low serum sodium concentrations in the blood are called hyponatremia, a prevalent clinical electrolyte disorder. In contrast ...

Microglia are the brain’s immune cells playing an important role in maintaining neural function and responding to potential ...

Low serum sodium concentrations in blood are called hyponatremia, a prevalent clinical electrolyte disorder. In contrast to acute hyponatremia, chronic hyponatremia has been previously considered ...

Dr Michael-John Dolan, a scientist at Trinity College Dublin. has won a highly prestigious European Research Council (ERC) ...

However, when the brain is subjected to hyperosmotic stress-;a condition characterized by elevated extracellular sodium levels, the microglial response can become exaggerated, leading to ...

The scientist will focus on brain repair as a model system, with the ultimate goal of harnessing microglial states.

"We propose that two different types of microglial cells -- the immune cells of the brain -- begin the process of amyloid and tau accumulation that define Alzheimer's disease," De Jager says.

During the disease’s early stages, a subset of microglia ramped up. These cells increased inflammation and accumulated toxic proteins. “We propose that two different types of microglial cells—the ...

Perlmutter explained, “[i]t is now clear that metabolic dysfunction upstream of amyloid plaque formation is central to the activation of the brain’s microglial cells, and this phenotypic ...

The '100 Million Cell Challenge' invites proposals for large-scale single cell studies, with CZI funding 50 million cells to accelerate scientific discoveries. A recent study reveals that 25% of ...