先前的研究表明，生物钟的紊乱会影响结直肠癌的进展，但直到现在，生物钟和癌症是如何影响肠道微生物群的还不清楚。使用结直肠癌小鼠模型，研究小组发现，当生物钟被打乱时，肠道细菌的多样性和丰度会发生变化，而癌症的发展会进一步加剧这种变化。

加州大学尔湾分校的研究揭示了生物钟 (人体内部的24小时生物起搏器)的破坏如何通过影响肠道微生物群和肠道屏障功能来加速结直肠癌的进展。这一发现为预防和治疗策略提供了新的途径。

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