Dendritic cells (DCs) are heterogeneous. The migratory DCs traffic from tissues to lymph nodes, where they mature. The resident DCs spend their entire lifespan in the lymphoid organs in an ...

Dendritic cells (DCs) are critical in the maintenance of self-tolerance and altered functions of DCs have been implicated in the pathogenesis of a number of autoimmune diseases, such as rheumatoid ...

Immunicum is developing a novel class of immunotherapies based on dendritic cells. These cells are orchestrators of the immune response due to their key role in bridging the gap between innate ...

经过重编程的肿瘤细胞重塑了肿瘤微环境，招募并扩增了多克隆细胞毒性T细胞，诱导肿瘤消退，并在多种小鼠黑色素瘤模型中建立了长期的系统性免疫耐受。在人类肿瘤类器官以及异种移植小鼠模型中，重编程为免疫原性树突状样细胞的过程独立于通常限制免疫疗法的免疫抑制。这 ...

One major reason why it has been difficult to develop an effective HIV vaccine is that the virus mutates very rapidly, ...

A collaboration between four MIT groups, led by principal investigators Laura L. Kiessling, Jeremiah A. Johnson, Alex K.

When protein antigens are injected into the small intestine of wild-type mice, they are passed to dendritic cells in the Peyer's patches; similar experiments in M-cell-deficient mice result in fewer ...

Researchers have shown that they can generate a strong immune response against HIV with two doses of a vaccine given one week apart.

This progressive, nearly inevitable process has long been hypothesized as a consequence of nature's removal of dendritic ...

系统性红斑狼疮（Systemic Lupus Erythematosus, SLE）是一种系统性自身免疫病，以全身多系统多脏器受累、反复的复发与缓解、体内存在大量自身抗体为主要临床特点，如不及时治疗，会造成受累脏器的不可逆损害，最终导致患者死亡。

In a study published in Advanced Functional Materials, a research team from the Shanghai Institute of Materia Medica (SIMM) ...

This valuable work analyzes how specialized cells in the auditory cells, known as the octopus cells, can detect coincidences in their inputs at the submillisecond time scale. While previous work ...