To investigate this, Thomas and colleagues developed a potent and selective semisynthetic GPBAR1 agonist — α-ethyl-23(S)-methyl-cholic acid (referred to as INT-777) — based on the human bile ...

mPEG-AcA由mPEG（甲氧基聚乙二醇）和丙烯酰胺两部分组成。mPEG片段提供了亲水性和生物相容性，而丙烯酰胺基团则赋予了其特殊的化学性质和功能。 mPEG-AcA的分子结构是由许多重复的单元组成的，这些单元之间通过酯键连接在一起。这种结构使得mPEG-AcA具有良好的 ...

FA-PEG-CLS，FA是一种用于生物标记和荧光检测的常见染料。PEG是一种长链聚合物，具有亲水性和生物相容性。CLS是一种常用的化学反应剂，能够与硫醇基团进行共价结合。 FA-PEG-CLS可以用于标记生物分子和细胞，以便在显微镜下进行观察和追踪。同时，马来酰亚胺 ...

The highlight of the evening was the story of Sahir Ludhianvi and Amrita Pritam, narrated artfully by Acharjya and Sujoy ...

In human bile, the main bile acids are cholic (a trihydroxy-bile acid) and chenodeoxycholic (a dihydroxy-bile acid). Deoxycholic acid appears to be a bacterial metabolite of cholic acid.

As well as having a role in lipid absorption, bile acids can act as endocrine-signaling molecules. With previous studies suggesting that bile acids operate as metabolic integrators, Watanabe et al.

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AIM To synthesise fatty acid bile acid conjugates (FABACs) and study their effects on cholesterol crystallisation in bile in vitro and in vivo. METHODS FABACs were prepared by conjugation of cholic ...

Objective Inflammatory bowel disease (IBD) is a multifactorial immune-mediated inflammatory disease of the intestine, comprising Crohn’s disease and ulcerative colitis. By characterising metabolites ...

(NASDAQ: MIRM) today announced that on September 10, 2024, the Compensation Committee of Mirum’s Board of Directors granted ...