接下来，研究团队确认了神经递质CGRP同样可以促进Th1细胞的分化，这与鉴定的RAMP3在T细胞中的调控作用一致。进一步运用RAMP3基因敲除的T细胞，研究者揭示了CGRP是通过T细胞表达RAMP3发挥调节作用。转录组测序显示CGRP激活T细胞中第二信使cAMP通路，cAMP的作用与CGRP高度一致，同样可以促进Th1细胞的分化。结合CUT&Tag测序、Luciferase、Western等实验， ...

T helper (TH) cells are essential immune cells that help other immune cells function effectively. When activated in response to environmental stimuli, these cells can differentiate into either TH1 ...

T helper (TH) cells are essential immune cells that help other immune cells function effectively. When activated in response ...

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A new study published in the journal PNAS offers insights into the biological mechanism behind this connection. Using fruit ...

Most plants and animals are exposed to a wide range of environmental variations. A study published in the journal Nature and ...

This study presents valuable insights into the organization of second-order circuits for gustatory neurons, particularly how they integrate opposing taste inputs and the metabolic states that regulate ...

New insights into the brain could pave the way for targeted treatments for anxiety, depression, and other mental health ...

Most plants and animals are exposed to a wide range of environmental variations. A study published in the journal Nature and ...

Penn Ovarian Cancer Research Center and Basser Center for BRCA, University of Pennsylvania, Perelman School of Medicine, Philadelphia, United States ...