In mice with symptomatic prion disease, microglia partially envelop many neurons. This correlates with worsening infection, beginning two weeks before symptoms. Neuron engulfment may mark a shift from ...

New research shows that microglia, which usually clear debris, cause harmful inflammation in the presence of APOE4 protein.

Understanding the role of microglia is helping scientists work toward improved treatments for neurodegenerative diseases.

追问快读： 长期以来，靶向神经递质血清素的药物一直被用于治疗抑郁症。而如今，研究重点正转向大脑化学的其他方面。在本期节目中，神经药理学家约翰·克里斯塔尔（John Krystal）分享了最新的研究成果，这些发现可能会颠覆我们对抑郁症的理解。

Torrents of data from cell atlases, brain organoids and other methods are finally delivering answers to an age-old question.

POLK expression in neurons and report an important observation that POLK exhibits an age-dependent change in subcellular localization, from the nucleus in young tissue to the cytoplasm in old tissue.

引言阿尔茨海默症（Alzheimer’s disease, AD）的临床前期（preclinical ...

Microglia affect the density of neuronal connections. Microglial cells (stained in green), the immune cells of the mouse brain, send branches into areas with many neuronal connections (stained blue).

More information: Hannah Scheiblich et al, Microglia rescue neurons from aggregate-induced neuronal dysfunction and death ...

Their research is published in the journal Nature Communications. Stroke negatively influences interaction of microglia and ...

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