Derived from macrolides, ketolides feature side-chain modifications that add acid stability and reduce the development of resistance. Telithromycin was the first ketolide approved for use in the U ...

macrolides and ketolides, glycopeptides and polymyxins (also known as colistin). These antibiotics are essential as last-resort treatments for multidrug-resistant infections in humans.

By the time this issue goes to press, telithromycin, of the new ketolides (derivatives of macrolides), will have been approved. Other than quinupristin-dalfopristin and cephalosporin derivatives ...