Therefore, cells have mechanisms in place to control protein quality. In animal and human cells, chaperones of the Hsp70 ...

Therefore, cells have mechanisms in place to control protein quality. In animal and human cells, chaperones of the Hsp70 class are at the heart of this control system, overseeing a wide array of ...

Two recent reports show that the co-chaperone CHIP mediates ubiquitin-dependent degradation of substrates bound to heat-shock protein 70 (Hsp70) and/or Hsp90. Figure 1: Models for the involvement ...