Researchers have found that targeting a class of sugar-modified proteins enhances cell repair, restores lost neurons, and ...

What it means for Denali Therapeutics to win the race across the blood-brain barrier to treat a rare genetic disease that ...

Heparanase is the only endoglycosidase in mammals which cleaves heparan sulfate (HS), the main polysaccharide of cell surface and tumor-surrounding extracellular matrix, into fragments retaining ...

Denali Therapeutics (NASDAQ:DNLI) said it plans to file for FDA accelerated approval of its drug candidate tividenofusp alfa, ...

This innovative bonding technique imitates the natural situation of the natural antithrombotic effect of heparan sulfate, thus presenting a 'blood-friendly' surface. Excellent and pliable handling ...

Although the exact mechanism by which TgPDCD5 enters host cells is not fully understood, studies suggest that it may do so via endocytosis induced by interaction with heparin or heparan sulfate ...

The independent validation of the genes involved in venom sensitization revealed that knockout experiments targeting each component of the heparin or heparan biosynthesis pathway resulted in some ...

Researchers have discovered an antibody able to neutralize all known variants of SARS-CoV-2, the virus that causes COVID-19, as well as distantly related SARS-like coronaviruses that infect other ...

They found that the venom’s toxins attach themselves to a sugar known as heparan sulphate, so by editing out the genes that produce heparan sulphates, cells became more resilient to venom.

In atherosclerosis, the vascular smooth muscle cell (VSMC) contributes to vessel wall inflammation and lipoprotein retention, as well as to the formation of the fibrous cap that provides stability ...