Endothelin (ET) is a recently discovered 21-amino acid peptide that has potent physiologic and pathophysiologic effects that appear to be involved in the development of heart failure. These ...
Endothelin is a peptide hormone known for its vasoconstrictive effects. Researchers at University of Tsukuba used cryo-electron microscopy to examine the complex structure of the endothelin ...
Endothelin is a peptide hormone known for its vasoconstrictive effects. Researchers at University of Tsukuba used cryo-electron microscopy to examine the complex structure of the endothelin receptor ...
ASCEND was a multicenter, placebo-controlled trial that aimed to investigate the effects of the endothelin-A (ET A) receptor antagonist avosentan in patients with diabetic nephropathy. The study ...
The efficacy and safety of the selective endothelin type A receptor antagonist atrasentan in reducing proteinuria in patients with IgA nephropathy are incompletely understood. We are conducting a ...
Novartis is advancing the late-stage development of two additional IgAN therapies: atrasentan, an investigational oral ...
Vera Therapeutics has shown the effect of atacicept on kidney function in patients with immunoglobulin A nephropathy persists ...
Article Google Scholar Edery P, Attié T, Amiel J, Pelet A, Eng C, Hofstra RMW, Bidaud C, Munnich A, Lyonnet S: Mutation of the endothelin-3 gene in the Waardenburg-Hirschsprung disease.
One type of drug used to treat PAH is endothelin receptor antagonists. ERAs, as they are called, help keep blood vessels from narrowing. But these drugs don’t work as well for Black patients as ...
HC Wainwright restated their buy rating on shares of Ligand Pharmaceuticals (NASDAQ:LGND – Free Report) in a report published ...
Atrasentan previously demonstrated efficacy in the open-label AFFINITY basket trial, where it reduced the 24-hour urinary ...
Atrasentan is associated with a significant and clinically meaningful reduction in proteinuria compared with placebo in ...