该研究表明，非编码DNA的损伤往往被隐藏了，它们在增殖缓慢的组织中积累得更多（例如肝脏或肾脏）。与频繁再生的器官不同，这些增殖缓慢的器官中的非编码DNA损伤长期未被发现，进而阻碍了细胞分裂。这些发现解释了什么有些器官（例如肝脏）比其他器官衰老得更快， ...

▎药明康德内容团队编辑  在早期胚胎发育过程中，从最初的受精卵开始，一次次有丝分裂构成了不断生长的胚胎。而每一次分裂都伴随着DNA复制，以确保每个子代细胞都含有完整的遗传信息。当然，这是理想状态。实际情况是，在早期胚胎发育过程中，DNA复制时常出错、导致染色体分离异常，并且这种异常出现的频率明显高于体细胞 ...

In this study, the investigators ablated liver cells in a mouse model, so they could assess liver cells or hepatocytes as ...

▎药明康德内容团队编辑  随着年龄增长，组成身体的各个组织器官并不是同步衰老的。很多人可能会从皮肤、头发上看出一个人衰老的迹象，实际上体内有些器官比皮肤老得更快。例如肝脏，作为人体最大的代谢器官，是衰老过程中首当其冲的器官之一。肝脏呈现出炎症和纤维化 ...

Damage to non-coding DNA accumulates more in slowly proliferating tissues, contributing to different rates of aging across ...

An article by UAB professor Joan-Ramon Daban analyzes in depth the physical problems associated with DNA packaging that have ...

An article by UAB professor Joan-Ramon Daban analyzes in depth the physical problems associated with DNA packaging that have ...

▎药明康德内容团队编辑（来源：上海科技大学）近日，上海科技大学生命科学与技术学院孙博课题组与广州医科大学附属妇女儿童医疗中心李卫课题组合作在国际学术期刊《自然-通讯》（Nature Communications）在线发表题为“RPA ...

A new process, nucleophagy, repairs damaged DNA that is particularly relevant for patients undergoing colorectal cancer ...

September/2092024/CH-8.jpg" width="1200" height="675" /> CBSE 2024-25 Competency-Based Questions With Answers: Assessment is vital in the learning process as it reinforces the knowledge of the ...

Zhijian “James” Chen received this year’s Albert Lasker Award for discovering cGAS, an enzyme which scopes out DNA-based ...