Polyketide - Wikipedia
网页Because of this diversity, polyketides can have various medicinal, agricultural, and industrial applications. Many polyketides are medicinal or exhibit acute toxicity. Biotechnology has enabled discovery of more naturally-occurring polyketides and evolution of new polyketides with novel or improved bioactivity.
Polyketide - an overview | ScienceDirect Topics
网页To facilitate the design of appropriate pathways to link and coordinate primary metabolism with polyketide biosynthesis, we first summarize the currently available precursor supply pathways (native, or heterologous) for polyketide biosynthesis.
Polyketide - an overview | ScienceDirect Topics
网页Polyketides are assembled by polyketide synthase (PKS) enzymes. PKS enzymes operate similarly to fatty acid synthase to generate a diverse range of PKs. PKS enzymes begin the PK assembly by priming the starter molecule to the catalytic residue, and then it employs an extender unit for the chain elongation.
Polyketides - SpringerLink
网页Polyketide synthases of type I are mainly found in filamentous fungi (Frisvad et al. 2020; Fujii 1999; Taura et al. 2016) and in bacteria (Tsai and Ames 2009; Shen 2003), and more particularly in actinomycetes (Dhakal et al. 2019).
Structure of a modular polyketide synthase | Nature
网页2014年6月18日 · Polyketide synthases are multidomain enzymes that produce polyketides, which form the basis of many therapeutic agents; here, electron cryo-microscopy is used to establish the structure of a ...
An artificial pathway for polyketide biosynthesis - Nature
网页2020年7月17日 · Polyketide synthases are multi-domain enzymes that catalyse the construction of many bioactive natural products. Now, some of the inefficiencies and limitations of these systems have been solved...
Chapter 1 Introduction to Polyketide Biosynthesis
网页2009年1月1日 · Generic reaction scheme for biosynthesis of both fatty acids and polyketides, illustrating how the basic reaction cycle of fatty acid biosynthesis can be shunted to generate diverse polyketide structures, incorporating different levels of reduction. PKSs that practice each type of chemistry are indicated. 1.1.
网页polyketide-derived structures found in nature. Three major themes broadly describe the organization of polyketide synthases from diverse organisms, based in part on the well-established paradigms for FAS complexes (Fig. 4). Type I and type II PKSs are structurally analogous to the type I FASs found in fungi, animals, and certain
Recent Advances in Understanding and Engineering Polyketide …
网页2016年2月23日 · Polyketides are a diverse group of natural products that form the basis of many important drugs. The engineering of the polyketide synthase (PKS) enzymes responsible for the formation of these compounds has long been considered to have great potential for producing new bioactive molecules.
Structure and function of polyketide biosynthetic enzymes: …
网页2017年12月2日 · Polyketides exhibit a high degree of structural diversity, although they are synthesized from simple acyl building blocks. Recent biochemical and structural studies provide a better understanding of the biosynthetic logic of polyketide diversity.