Fetuin - Wikipedia
网页Fetuins are members of a family of proteins that evolved from the protein cystatin by gene duplication and exchange of gene segments. Fetuins thus belong to the cystatin superfamily of proteins. Fetuin relatives within this superfamily are the histidine -rich glycoprotein (HRG) and kininogen (KNG). Α2-HS-glycoprotein.
The structure, biosynthesis, and biological roles of fetuin-A: A review
网页2022年7月18日 · Fetuin-A, formerly known as phosphoprotein 63 KDa (pp63) or countertrypin, is a plasma carrier protein that helps to transport and make a wide range of substances available in the bloodstream.
Fetuin-A is a HIF target that safeguards tissue integrity during ...
网页2021年1月22日 · Here the authors identify fetuin-A as a HIF target gene and describe its protective role in the kidney, counteracting disease mechanisms such as calcification, macrophage polarization, and...
Fetuin - an overview | ScienceDirect Topics
网页2010年1月1日 · Fetuin is a glycoprotein released mainly by the liver that has various effects on cancer, cardiovascular diseases, obesity, diabetes, and calcification. It acts as a major serum inhibitor of apatite crystal growth, reducing inflammation and macrophage activation by facilitating the clearance of mineral crystals deposited in tissues.
Fetuin - an overview | ScienceDirect Topics
网页Fetuin-A stabilizes colloidal nanoscopic complexes with Ca and P and prevents crystal growth by shielding mechanisms. We termed the complex “calciprotein particles” because they share functional and structural similarities to …
Fetuin - an overview | ScienceDirect Topics
网页Fetuin-A is a glycoprotein mainly produced by hepatocytes, but also is secreted by paracrine, autocrine, and endocrine glands into the circulation. Fetuin-A is a hepatokine that acts on insulin and regulates blood glucose secreted by the liver [85]. In 1944, fetuin-A was first detected in fetal calf serum and reported to decrease with age [86].
The Evolving Role of Fetuin-A in Nonalcoholic Fatty Liver Disease: …
网页2021年6月21日 · Fetuin-A, also known as alpha-2-Heremans-Schmid glycoprotein, is abundantly synthesized and secreted by the liver. It is found in the extracellular space throughout the body . Fetuin-A is a multifaceted protein playing a role in various cellular pathways including calcium and bone metabolism, insulin resistance and inflammation.
The structure, biosynthesis, and biological roles of fetuin-A
网页2022年7月18日 · Fetuin-A is a heterodimeric plasma glycoprotein containing an A-chain of 282 amino acids and a B-chain of 27 amino acid residues linked by a single inter-disulfide bond. It is predominantly expressed in embryonic cells and adult hepatocytes, and to a lesser extent in adipocytes and monocytes.
Fetuin-A: a multifunctional protein - PubMed
网页Fetuin, first isolated from fetal bovine serum and now most commonly known as either fetuin-A, alpha-2-HS-glycoprotein (recommended name by UniprotKB and PIR), or α2-Heremans-Schmid glycoprotein, functions as an important component of diverse normal and pathological processes, including vascular calcification and bone metabolism regulation ...
Fetuin-A and its genetic association with cardiometabolic disease
网页2023年12月6日 · Fetuin-A, also known as α-Heremans-Schmid glycoprotein (AHSG), is a liver-synthesized protein that acts as a systemic inhibitor of ectopic calcification 1. This protein can additionally inhibit...