HSF1 Gene - GeneCards | HSF1 Protein | HSF1 Antibody
网页2024年8月6日 · GeneCards Summary for HSF1 Gene. HSF1 (Heat Shock Transcription Factor 1) is a Protein Coding gene. Diseases associated with HSF1 include Heat-Shock Rna 1 and Erythroleukemia. Among its related pathways are Selective autophagy and Cellular response to heat stress.
Heat shock factor protein 1 - Wikipedia
网页Heat shock factor protein 1 (HSF 1) is a protein that in humans is encoded by the HSF1 gene. [4] HSF1 is highly conserved in eukaryotes and is the primary mediator of transcriptional responses to proteotoxic stress with important roles in non-stress regulation such as development and metabolism. [5]
Molecular mechanisms of heat shock factor 1 regulation
网页2022年3月1日 · Highlights. Hsf1 is a thermosensor itself and directly senses elevated temperatures with conformational changes in the leucin zipper domains HR-A/B and HR-C. Hsp70, not Hsp90 as proposed in many studies, is the main chaperone regulating Hsf1 activity by monomerizing Hsf1 trimers and thereby dissociating Hsf1 from DNA.
HSF1Base: A Comprehensive Database of HSF1 (Heat Shock Factor ... - PubMed
网页2019年11月19日 · HSF1 (heat shock factor 1) is an evolutionarily conserved master transcriptional regulator of the heat shock response (HSR) in eukaryotic cells. In response to high temperatures, HSF1 upregulates genes encoding molecular chaperones, also called heat shock proteins, which assist the refolding or degr ….
The Emerging Role of Heat Shock Factor 1 (HSF1) and Heat Shock …
网页2023年3月14日 · Among the HSFs, HSF1 plays a major role in the heat shock response. On activation, HSF1 interacts with heat shock elements within the target heat shock gene promotors, inducing various HSPs expression. The activated HSPs either support the refolding of misfolded proteins or target them for proteasomal degradation [7].
HSF1 heat shock transcription factor 1 [ (human)] - National …
网页HSF1 expression in tumor-associated macrophages promotes tumor cell proliferation and indicates poor prognosis in esophageal squamous cell carcinoma. Heat shock factor 1 is a promising therapeutic target against adult T-cell leukemia.
HSF1 phase transition mediates stress adaptation and cell fate ... - Nature
网页2020年2月3日 · Here we report that condensation and phase transition of heat-shock factor 1 (HSF1), a transcriptional regulator of chaperones1,2, is integral to cell-fate decisions underlying survival or death...
The Multifaceted Role of HSF1 in Pathophysiology: Focus on Its ...
网页2021年6月14日 · HSF1 is the main regulator of the heat shock response (HSR), the master pathway required to maintain proteostasis, as involved in the expression of the heat shock proteins (HSPs). HSF1 plays numerous physiological functions; however, the main role concerns the modulation of HSPs synthesis in response to stress.
HSF1 at a glance - PubMed
网页2014年1月15日 · Heat shock factor 1 (HSF1) is an evolutionarily highly conserved transcription factor that coordinates stress-induced transcription and directs versatile physiological processes in eukaryotes. The central position of HSF1 in cellular homeostasis has been well demonstrated, mainly through its strong ….
Structure of human heat-shock transcription factor 1 in complex …
网页2016年1月4日 · Heat-shock transcription factor 1 (HSF1) has a central role in mediating the protective response to protein conformational stresses in eukaryotes. HSF1 consists...