Endothelin - Wikipedia
网页Endothelin. Endothelins are peptides with receptors and effects in many body organs. [1][2][3] Endothelin constricts blood vessels and raises blood pressure.
Endothelin: Function and Purpose - Cleveland Clinic
网页This peptide, or small protein, helps regulate blood pressure by constricting blood vessels. When you make too much endothelin, you may develop high blood pressure, as well as heart and lung issues. Endothelin receptor antagonists …
Physiology, Endothelin - StatPearls - NCBI Bookshelf
网页2023年5月1日 · Endothelin is a 21-amino acid long peptide that is a vasoconstrictor produced from endothelial cells, vascular smooth muscle cells (VSMC), macrophages, and the renal medulla. They are known to produce endothelin-1 …
Endothelins in cardiovascular biology and therapeutics - Nature
网页2019年3月13日 · Endothelin 1 (ET-1) is the most potent endogenous vasoconstrictor and contributes to basal vascular tone as well as a number of diseases, such as hypertension, chronic kidney disease (CKD ...
Endothelin: 30 Years From Discovery to Therapy | Hypertension
网页2019年11月4日 · Photographs courtesy of Yoshitoshi Kasuya and Paul Vanhoutte. An endothelium-derived 21-residue vasoconstrictor peptide, endothelin, has been isolated, and shown to be one of the most potent vasoconstrictors known.
Endothelin and the Cardiovascular System: The Long Journey ...
网页2022年5月16日 · In this review, we describe the basic functions of endothelin and related molecules, including their receptors and enzymes. Furthermore, we discuss the important role of endothelin in several cardiovascular diseases, the relevant clinical evidence for targeting the endothelin pathway, and the scope of …
Endothelin - an overview | ScienceDirect Topics
网页Endothelin is an endothelial cell marker of interest in preeclampsia. Of the three isoforms of endothelin, ET-1 is the predominant one produced in endothelial cells224 and exerts its biological actions in a paracrine fashion …
Endothelin: 30 Years From Discovery to Therapy - PubMed
网页Here, we summarize the main clinical trials using ERAs and discuss the role of endothelin in cardiovascular diseases such as arterial hypertension, preecclampsia, coronary atherosclerosis, myocardial infarction in the absence of obstructive coronary artery disease (MINOCA) caused by spontaneous coronary artery dissection (SCAD), Takotsubo ...
Endothelin - PubMed
网页The endothelins comprise three structurally similar 21-amino acid peptides. Endothelin-1 and -2 activate two G-protein coupled receptors, ETA and ETB, with equal affinity, whereas endothelin-3 has a lower affinity for the ETA subtype. Genes encoding the peptides are present only among vertebrates.
Endothelin - PMC - National Center for Biotechnology Information
网页2010年9月17日 · Recently, a new endothelin peptide with 31 amino acids has been identified in humans. This endothelin is formed through the cleavage of the big endothelin-1 between the Tyr 31 and Gly 32 amino acids by a human …