A-FABP in Metabolic Diseases and the Therapeutic Implications: …
网页2021年8月30日 · Adipocyte fatty acid-binding protein (A-FABP), which is also known as ap2 or FABP4, is a fatty acid chaperone that has been further defined as a fat-derived hormone. It regulates lipid homeostasis and is a key mediator of inflammation.
A-FABP mediates adaptive thermogenesis by promoting ... - Nature
网页2017年1月27日 · The adipokine adipocyte fatty acid-binding protein (A-FABP) has been implicated in obesity-related cardio-metabolic complications. Here we show that A-FABP increases thermogenesis by...
Fatty acid-binding proteins: role in metabolic diseases and
网页Adipocytes and macrophages jointly express two FABPs: A-FABP (also known as aP2/FABP4) and E-FABP (also known as mal1/FABP5), which are the best-studied FABPs. They play a central role in many...
脂肪酸结合蛋白4 - 百度百科
网页脂肪酸结合蛋白 (fatty acid-binding protein,FABP)是胞内脂质结合蛋白超家族成员,存在于 脊椎动物 和无脊椎动物的细胞内,在长链脂肪酸的摄取、转运及代谢调节中发挥重要作用,并涉及生物体的其他生命过程。. [1] FABPs 在细胞内的作用是促进脂肪酸增溶、 运输和 ...
Adipocyte Fatty Acid Binding Protein (A-FABP) as a Potential …
网页Fatty acid binding protein A (A-FABP) is one of FABPs isoforms found mainly in adipose tissue and macrophages. It works through many integrated pathways, regulating inflammation and lipid metabolism, promoting glucose production, impairing insulin function, and contributing to diseases such as ather ….
Fatty Acid-Binding Protein 4 (FABP4): Pathophysiological Insights …
网页2015年2月2日 · Fatty acid-binding protein 4 (FABP4), also known as adipocyte FABP (A-FABP) or aP2, is mainly expressed in adipocytes and macrophages and plays an important role in the development of insulin resistance and atherosclerosis in relation to metaflammation.
Circulating Adipose Fatty Acid Binding Protein Is a New ... - Cell …
网页2018年11月6日 · Hao et al. show that circulating adipose fatty acid binding protein (A-FABP) increases in obesity and promotes breast cancer by increasing mammary tumor stemness and aggressiveness through an IL-6/STAT3/ALDH1 axis. A-FABP could be a potential therapeutic target for obesity-associated cancers.
Fatty acid-binding protein 4 is a therapeutic target for ... - Nature
网页2022年4月11日 · Growing evidence suggests that fatty acid-binding protein 4 (FABP4) is critically involved in kidney diseases, while its role in septic AKI remains unknown.
SnapShot: FABP Functions - Cell Press
网页2020年8月20日 · This Snapshot describes the overall functions of FABPs in health and disease and highlights emerging roles of adipose FABP (A-FABP) and epidermal FABP (E-FABP) in the fields of obesity, chronic inflammation, and cancer development.
SnapShot: FABP Functions - PubMed
网页2020年8月20日 · This Snapshot describes the overall functions of FABPs in health and disease and highlights emerging roles of adipose FABP (A-FABP) and epidermal FABP (E-FABP) in the fields of obesity, chronic inflammation, and cancer development.
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